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Symbol Name ID |
Dicer1
dicer 1, ribonuclease type III MGI:2177178 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Sertoli cell neoplasm |
Testicular seminoma |
Ovarian neoplasm |
Uterine leiomyosarcoma |
| Disease(s) Associated with DICER1 | ||||
| colorectal cancer | ||||
| multinodular goiter |
| Mouse Phenotypes | reproductive system phenotype |
abnormal sperm flagellum morphology |
thin sperm flagellum |
abnormal sperm midpiece morphology |
abnormal sperm mitochondrial sheath morphology |
absent sperm mitochondrial sheath |
absent sperm fibrous sheath |
kinked sperm flagellum |
abnormal oocyte morphology |
azoospermia |
oligozoospermia |
teratozoospermia |
abnormal sperm head morphology |
abnormal acrosome morphology |
abnormal sperm nucleus morphology |
small sperm head |
pinhead sperm |
abnormal male germ cell morphology |
abnormal spermatid morphology |
abnormal manchette morphology |
ectopic manchette |
decreased male germ cell number |
abnormal female meiosis |
abnormal spindle assembly in female meiosis |
abnormal meiotic spindle morphology |
increased male germ cell apoptosis |
increased Sertoli cell proliferation |
decreased endometrial gland number |
decreased ovary weight |
abnormal seminiferous tubule epithelium morphology |
abnormal Sertoli cell morphology |
ectopic Sertoli cells |
small seminiferous tubules |
seminiferous tubule degeneration |
increased Leydig cell number |
decreased testis weight |
small testis |
testis degeneration |
abnormal oviduct morphology |
short oviduct |
abnormal uterus morphology |
thin myometrium |
short uterine horn |
decreased uterus weight |
small uterus |
abnormal spermatogenesis |
abnormal spermiogenesis |
abnormal efferent ductules of testis morphology |
dilated efferent ductule of testis |
abnormal epididymis morphology |
abnormal epididymis epithelium morphology |
small epididymis |
abnormal oviduct transport |
decreased superovulation rate |
decreased ovulation rate |
abnormal pregnancy |
failure of embryo implantation |
female infertility |
male infertility |
increased epididymal epithelium cell proliferation |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Dicer1em1Psv/Dicer1em1Psv | * | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Dicer1em2Psv/Dicer1em2Psv | * | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Dicer1em3Psv/Dicer1em3Psv | * | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Dicer1tm1Bdh/Dicer1tm1Bdh Plekha5Tg(AMH-cre)1Flor/Plekha5+ (conditional) |
* | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Dicer1tm1Bdh/Dicer1tm1Bdh Amhr2tm3(cre)Bhr/Amhr2+ (conditional) |
* | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Dicer1tm1Bdh/Dicer1tm1Bdh Defb41tm1(icre)Psip/Defb41+ (conditional) |
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| Dicer1tm1Bdh/Dicer1tm1Bdh Tg(NEUROG3-cre)1Herr/0 (conditional) |
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| Alpltm1(cre)Nagy/Alpl+ Dicer1tm1.1Mnn/Dicer1tm1.2Mnn (conditional) |
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| Dicer1tm1.1Mnn/Dicer1tm1.2Mnn Tg(Zp3-cre)93Knw/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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